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Overview
Personalized RNA neoantigen vaccines are designed against each patient’s tumor-specific mutations to direct T cells against cancer-defining epitopes.
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Nature 618(7963), 144–150 · 2023
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
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Overview
Personalized RNA neoantigen vaccines are designed against each patient’s tumor-specific mutations to direct T cells against cancer-defining epitopes.
Findings
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer (Nature, 2023) and prime long-lived CD8+ T cells (Nature, 2025), supporting the durability of vaccine-induced immune responses.