sPARK.
Wungki Park, MD, MS
Principal Investigator

Wungki Park, MD, MS

MSK Profile →LinkedIn →Google Scholar →X (Twitter) →ORCID 0000-0002-8006-3102 →

Gastrointestinal medical oncologist and physician-scientist at Memorial Sloan Kettering Cancer Center, specializing in pancreatic and biliary tract cancers. His clinical and translational research focuses on pancreatic cancer immunobiology, DNA damage repair, KRAS/RAS-directed therapeutics, therapeutic resistance, and biomarker-driven precision oncology.

He led the POLAR trial of maintenance pembrolizumab plus olaparib in metastatic pancreatic cancer (Nature Medicine) and has contributed to individualized mRNA neoantigen vaccines, clinicogenomic studies of KRAS mutant alleles and dosage, and the clinical development of novel KRAS-directed therapies including setidegrasib and daraxonrasib.

Through the GRIT (GI RAS Innovative Therapeutics) initiative he is extending RAS-directed precision therapy across gastrointestinal cancers, connecting human tumor biology with mechanism-guided clinical trial design.

Publications

N Engl J Med · 2026Daraxonrasib in Previously Treated Advanced RAS-Mutated Pancreatic CancerNature Medicine · 2026Pembrolizumab and Olaparib in HRD Metastatic Pancreatic Cancer: The POLAR TrialN Engl J Med · 2026Setidegrasib in Advanced Non–Small-Cell Lung Cancer and Pancreatic CancerNature Medicine 31(2), 466–477 · 2025Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survivalNature 639(8056), 1042–1051 · 2025RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancerNature 636(8043), 728–736 · 2024Automated real-world data integration improves cancer outcome predictionCancer Cell 42(9), 1614–1629 · 2024Distinct clinical outcomes and biological features of specific KRAS mutants in human pancreatic cancerNature 618(7963), 144–150 · 2023Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancerNature Methods, 10.1038/s41592-022-01415-4 · 2022MITI minimum information guidelines for highly multiplexed tissue imagesJAMA Oncology 7(5), 735–738 · 2021Association of ablative radiation therapy with survival among patients with inoperable pancreatic cancerJNCI: Journal of the National Cancer Institute 113(9), 1194–1202 · 2021Early-onset pancreas cancer: clinical descriptors, genomics, and outcomesBlood 137(15), 2103–2113 · 2021Genomic profiling identifies somatic mutations predicting thromboembolic risk in patients with solid tumorsJAMA 326(9), 851–862 · 2021Pancreatic cancer: a reviewCancer 126(17), 3939–3949 · 2020Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinomaClinical Cancer Research 26(13), 3239–3247 · 2020Genomic methods identify homologous recombination deficiency in pancreas adenocarcinoma and optimize treatment selectionCancer Immunology, Immunotherapy 69(7), 1177–1187 · 2020Outcomes associated with immune-related adverse events in metastatic non-small cell lung cancer treated with nivolumab: a pooled exploratory analysis from a global cohortThe Lancet Oncology 20(6), 837–848 · 2019Axitinib plus pembrolizumab in patients with advanced sarcomas including alveolar soft-part sarcoma: a single-centre, single-arm, phase 2 trialThe Oncologist 24(6), 820–828 · 2019Clinical implications of circulating tumor DNA tumor mutational burden (ctDNA TMB) in non-small cell lung cancerJournal for Immunotherapy of Cancer 7(1), 131 · 2019Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshopJAMA Oncology 4(8), 1080–1084 · 2018Cost-effectiveness of Osimertinib in the First-Line Treatment of Patients With EGFR-Mutated Advanced Non–Small Cell Lung CancerMolecular Carcinogenesis 54(10), 1147–1158 · 2015Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancerAngiogenesis 16(4), 903–917 · 2013Antiangiogenic effects of ganetespib in colorectal cancer mediated through inhibition of HIF-1α and STAT-3Cancer Prevention Research 6(5), 387–400 · 2013New perspectives of curcumin in cancer prevention

All publications by Wungki Park →

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