Alterations in driver genes are predictive of survival in patients with resected pancreatic ductal adenocarcinoma

Summary

In patients with resected pancreatic ductal adenocarcinoma, KRAS and TP53 alterations were associated with worse outcomes, while homologous-recombination-deficiency gene alterations were associated with favorable prognosis. These clinical associations provide context for functional studies; they do not establish causal dependencies.