Publications

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1502 Tubular-Infiltrative Variant of Acinar Cell Carcinoma: Clinicopathologic Analysis of 11 Cases of A Distinct Entity Invariably Misdiagnosed as Ductal Adenocarcinoma

D Bahceci, N Tezcan, B Memis, W Park, E O'Reilly, D Klimstra, O Basturk, ...

Laboratory Investigation 106 (3)

sPARK LabEileen O'ReillyWungki Park
2026

1O ATOMIC (A021502/AIO-KRK-0317): Does duration of adjuvant chemotherapy (chemo) or immunotherapy matter?

A Reinacher-Schick, FS Ou, D Hsu, CH Lieu, D Cohen, K Matin, ...

Annals of Oncology 37, S2

Eileen O'Reilly
2026

342O Zolbetuximab plus gemcitabine and nab-paclitaxel (GN) in patients (pts) with claudin 18 isoform 2 (CLDN18. 2)+ metastatic pancreatic adenocarcinoma (mPAC): phase II GLEAM …

W Park, L Shen, MP Ducreux, S Mitsunaga, G Roth, B Shen, ...

Annals of Oncology 37, S124-S125

sPARK LabEileen O'ReillyWungki Park
2026

425P Arterial thromboembolism in pancreatic ductal adenocarcinoma: A marker of advanced disease and poor survival

A Syal, K Yu, W Park, C O'Connor, M Capanu, J Chou, C Schwartz, ...

Annals of Oncology 37, S154-S155

sPARK LabEileen O'ReillyWungki Park
2026

430P CLDN18. 2 and KRAS signaling shape tumor states and immune microenvironment in pancreatic cancer (PC)

V Nasca, M Hilmi, N Tezcan, M Perry, M May, J Song, F Balogun, ...

Annals of Oncology 37, S157

sPARK LabEileen O'ReillyFiyinfolu BalogunWungki Park
2026

472TiP RASolute 304: A phase III multicenter, open-label, randomized study of adjuvant daraxonrasib versus observation following completion of neoadjuvant and/or adjuvant …

MP Ducreux, D Chang, M Ikeda, A Lowy, TM Mercade, ZA Wainberg, ...

Annals of Oncology 37, S172

Eileen O'Reilly
2026

A phase 2/3 randomized study of BMS-986504 with nab-paclitaxel (nab-P) and gemcitabine (GEM) in first-line (1L) metastatic pancreatic ductal adenocarcinoma (PDAC) with …

S Pant, MP Ducreux, M Ikeda, X Yu, EM O'reilly, G Trandafirescu, ...

Journal of Clinical Oncology 44 (2_suppl), TPS796-TPS796

Eileen O'Reilly
2026

A Phase II Trial of an Extended-Release siRNA Implant Targeting KRASG12D/V in Locally Advanced Pancreatic Cancer

Alagesan B, Varghese AM, Ang C, Gutierrez M, Kamar M, Passhak M, Geva R, Yarom N, et al.

Clin Cancer Res

sPARK LabWungki ParkEileen O'Reilly
2026

Abstract A042: ctDNA KRAS detection in pancreatic ductal adenocarcinoma: Platform concordance, sensitivity and clinical associations in a contemporary cohort

J Guo, M May, MF Berger, E Cismas, M Hilmi, A Singhal, F Balogun, ...

Cancer Research 86 (18_Supplement_2), A042-A042

sPARK LabEileen O'ReillyFiyinfolu BalogunWungki Park
2026

Abstract A050: Mutant allele copy number gains define distinct molecular subtypes of oncogene-driven cancers and are associated with response to allele-specific KRASG12C …

MA Perry, AL Richards, A Price, SE Tischfield, H Walch, H Xie, ...

Cancer Research 86 (5_Supplement_1), A050-A050

sPARK LabEileen O'ReillyWungki Park
2026

Abstract A124: Prevalence, Treatment Patterns, and Outcomes of Organ Dysfunction at Diagnosis in Metastatic Pancreatic Ductal Adenocarcinoma: A Single-Institution Analysis of 3 …

E Cismas, RB Forman, J Zheng, Q Shi, W Park, M Pishvaian, ...

Cancer Research 86 (18_Supplement_2), A124-A124

sPARK LabEileen O'ReillyWungki Park
2026

Abstract A140: Patient-derived organoids and precision medicine: Insights from the PASS-01 clinical trial in PDAC

AN Habowski, FM Kouassi, J Rouse, J Hinds, H Patel, C Tsang, L Kelly, ...

Cancer Research 86 (18_Supplement_2), A140-A140

Eileen O'Reilly
2026

Abstract IA008: Pancreas cancer: Genomics, RAS therapeutics and clinical landscape

EM O'reilly

Cancer Research 86 (5_Supplement_1), IA008-IA008

Eileen O'Reilly
2026

Abstract LB337: Daraxonrasib monotherapy as first-line (1L) treatment for patients with metastatic pancreatic adenocarcinoma (mPDAC)

EM O'Reilly, B Wolpin, S Pant, JR Hecht, J Valerin, DW Kim, N Azad, ...

Cancer Research 86 (8_Supplement), LB337-LB337

Eileen O'Reilly
2026

Abstract LB423: Invigorating pre-existing tumor-infiltrating expandable (TIE) T cell clonotypes in exceptional responders with dual PARP-PD-1 blockade in homologous …

M Hilmi, W Mckerrow, JD Schoenfeld, S Umeda, N Tezcan, C O'Connor, ...

Cancer Research 86 (8_Supplement), LB423-LB423

sPARK LabEileen O'ReillyWungki Park
2026

Abstract SY36-02: Human cancer models: From patient-derived systems to clinical translation

AN Habowski, F Kouassi, H Patel, J Rouse, C Tsang, L Kelly, D Plenker, ...

Cancer Research 86 (8_Supplement), SY36-02-SY36-02

Eileen O'Reilly
2026

Addition of High-Dose Vitamin D3 to Standard Treatment in Patients With Metastatic Colorectal Cancer: The SOLARIS Randomized Clinical Trial (Alliance A021703)

K Ng, FS Ou, T Zemla, NA Jackson, A Kalyan, C Devoe, M Shusterman, ...

JAMA 336 (9), 746-754

Eileen O'Reilly
2026

Adjuvant Chemotherapy ± Chemoradiotherapy for Adenocarcinoma of the Pancreatic Head: Results of the Radiotherapy Random Assignment of NRG Oncology/RTOG 0848

Abrams RA, Winter KA, Goodman KA, Regine WF, Safran HP, Guha CS, Kachnic LA, Gillin MT, et al.

J Clin Oncol

Eileen O'Reilly
2026

Adjuvant Chemotherapy Alone or Combined with Atezolizumab in Patients with Stage III Deficient DNA Mismatch Repair (dMMR) Colon Cancer-Results of the Randomized ATOMIC Trial …

D Arnold, S Hegenberg, J von Tresckow, A Stahler, E Goekkurt, ...

ONCOLOGY RESEARCH AND TREATMENT 49, 11-12

Eileen O'Reilly
2026

Alliance A022104/NRG-GI010, a randomized phase II/III trial testing the efficacy of triplet versus doublet chemotherapy regarding clinical complete response and disease-free …

CS Kitchens, Q Shi, A Dasari, J Garcia-Aguilar, HK Sanoff, TJ George, ...

Journal of Clinical Oncology 44 (2_suppl), TPS279-TPS279

Eileen O'Reilly
2026

Alliance A221805: Duloxetine to Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Blind, Placebo-Controlled Phase II Study

Lavoie Smith EM, Lee M, Scott MR, Liu H, Hillman S, Rieken T, Wills R, Diaz-Cobo J, et al.

JCO Oncol Adv

Eileen O'Reilly
2026

Anatomical dynamics define cancer cachexia subtypes and identify systemic inflammation as a marker of lethal wasting

Boscenco S, Castillon VJ, Wang J, Tse E, Freeman SS, Bakouny Z, Mohan S, Guo XA, et al.

medRxiv

sPARK LabWungki ParkMichael MayEileen O'Reilly
2026

ASO Visual Abstract: Outcomes of First-versus Second-Line Hepatic Artery Infusion Chemotherapy in Unresectable Intrahepatic Cholangiocarcinoma

Nasar N, Armstrong M, Chou JF, Gonen M, Soares KC, Balachandran VP, Drebin JA, Kingham TP, et al.

Ann Surg Oncol

sPARK LabWungki ParkEileen O'Reilly
2026

Association of genomic and clinical factors with outcomes with front-line chemoimmunotherapy in patients with advanced biliary tract cancer.

OM Fitzpatrick, J Chou, J Xu, A Dhyani, DN Khalil, F Nagib, F Keane, ...

Journal of Clinical Oncology 44 (16_suppl), 4135-4135

sPARK LabEileen O'ReillyWungki Park
2026

Associations of WCRF/AICR recommendations with survival and chemotherapy outcomes in colon cancer: CALGB/SWOG 80702 (Alliance)

E Cheng, C Ma, Q Shi, AF Shields, PT Campbell, AP Shergill, KA Guthrie, ...

Cancer Research 86 (7_Supplement), 5038-5038

Eileen O'Reilly
2026

Atezolizumab and motixafortide, cobimetinib or simlukafusp alfa in pretreated advanced pancreatic cancer: phase I/IIb MORPHEUS-PDAC umbrella study

Manji GA, Chung V, Oh DY, Lacy J, Lopez CD, Ponz-Sarvisé M, Macarulla T, Thomas R, et al.

Oncologist

Eileen O'Reilly
2026

Atezolizumab plus FOLFOX for stage III mismatch repair–deficient colon cancer

FA Sinicrope, FS Ou, D Arnold, WR Peters, RJ Behrens, CH Lieu, K Matin, ...

New England Journal of Medicine 394 (12), 1155-1166

Eileen O'Reilly
2026

Availability and Use of Social Determinants of Health Data in Alliance Gastrointestinal Cancer Clinical Trials

Lewis KA, Colgrove BA, Nelson GD, Shi Q, Edwards GC, Katz MHG, Chang GJ, Paskett ED, et al.

JCO Oncol Pract

Eileen O'Reilly
2026

BI 905711, a TRAILR2/CDH17 Bispecific Antibody, Alone or with Chemotherapy for Patients with Advanced Gastrointestinal Cancers: Phase I Study Findings

JJ Harding, R Hofheinz, E Élez, Y Kuboki, DW Rasco, M Cecchini, L Shen, ...

Cancer Research Communications 6 (5), 1123-1135

Eileen O'Reilly
2026

Biomarker and pharmacokinetics (PK) analyses of zolbetuximab from the phase 2 GLEAM study in patients (pts) with claudin 18 isoform 2 (CLDN18. 2)+ metastatic pancreatic …

W Park, L Shen, MP Ducreux, S Mitsunaga, G Roth, B Shen, ...

ESMO Gastrointestinal Cancers Congress 2026

sPARK LabEileen O'ReillyWungki Park
2026

Cabozantinib for advanced grade 3 neuroendocrine tumors: subgroup analysis of the phase 3 CABINET trial (Alliance A021602)

JR Strosberg, T Zemla, S Geyer, S Pulsipher, FS Ou, S Behr, N Raj, ...

Endocrine-related cancer 33 (1)

Eileen O'Reilly
2026

Cancer type-specific variation in patterns of driver alterations across 50,000 tumors

C Bandlamudi, D Muldoon, I de Bruijn, M Zhang, MV Gormally, ...

Cancer cell 44 (5), 1045-1062. e6

Eileen O'Reilly
2026

Cergutuzumab Amunaleukin in Combination with Atezolizumab in Patients with Carcinoembryonic Antigen-Positive Advanced/Metastatic Solid Tumors

Melero I, Tabernero J, Steeghs N, Robbrecht DGJ, Peters S, Rizvi NA, O'Reilly EM, Calvo E, et al.

Clin Cancer Res

Eileen O'Reilly
2026

Characterization of antibody-drug conjugate target antigen expression in patients with biliary tract cancer.

A Dhyani, N Tezcan, J Chou, Z Tarcan, R Thummalapalli, F Nagib, ...

Journal of Clinical Oncology 44 (16_suppl), e15042-e15042

sPARK LabEileen O'ReillyWungki Park
2026

Clinical and translational results from a phase 1 trial of gemcitabine/nab-paclitaxel with nivolumab/ipilimumab or hydroxychloroquine/ipilimumab in untreated metastatic …

EM O’Reilly, CR Cabanski, JP Lyman, ZA Wainberg, GA Fisher, RA Wolff, ...

Journal for immunotherapy of cancer 14 (1), e012864

Eileen O'Reilly
2026

Convergence for Inactivation of TGFβ Signaling Is a Common Feature of Advanced Pancreatic Cancer

Hong J, Kohutek ZA, Zhang H, Lecomte N, Karnoub ER, Kappagantula R, Wood LD, O'Reilly EM, et al.

Cancer Discov

Eileen O'Reilly
2026

CONVERSION HEPATECTOMY FOLLOWING HEPATIC ARTERY INFUSION PUMP THERAPY FOR UNRESECTABLE INTRAHEPATIC CHOLANGIOCARCINOMA

M Mederos, R Harvey, M Gonen, A Nigam, L Saadat, K Soares, A Wei, ...

HPB 28, S87

Eileen O'Reilly
2026

Daraxonrasib monotherapy as first-line (1L) treatment for patients with metastatic pancreatic adenocarcinoma (mPDAC)

EM O’Reilly, B Wolpin, S Pant, JR Hecht, J Valerin, DW Kim, N Azad, ...

CANCER RESEARCH 86 (8)

Eileen O'Reilly
2026

Daraxonrasib or chemotherapy in previously treated metastatic pancreatic cancer

EM O’Reilly, ZA Wainberg, AE Hendifar, MJ Borad, F Pietrantonio, S Pant, ...

New England Journal of Medicine 395 (4), 325-337

Eileen O'Reilly
2026

Daraxonrasib, a RAS (ON) multi-selective inhibitor vs chemotherapy in previously treated metastatic pancreatic adenocarcinoma (mPDAC): Primary and final analysis from the phase …

BM Wolpin, ZA Wainberg, A Hendifar, MJ Borad, F Pietrantonio, S Pant, ...

Journal of Clinical Oncology 44 (17), LBA5-LBA5

Eileen O'Reilly
2026

Deep Learning Enabled 3D Multi-Omic Analysis Reveals Molecular Signatures of Heterogeneous Response to Chemotherapy in Pancreatic Cancer

Forjaz A, Mojdeganlou H, Valentin A, Wetzel M, Lvovs D, Deshpande A, Shin SM, Piya S, et al.

bioRxiv

sPARK LabWungki ParkEileen O'Reilly
2026

Dual pancreatic carcinomas: clonally related or independent primaries?

Schoenfeld JD, Ravichandran V, Tarcan Z, Sahin-Ozkan H, Richards AL, Bilani N, Chou JF, O'Connor CA, et al.

NPJ Precis Oncol

sPARK LabWungki ParkEileen O'ReillyFiyinfolu Balogun
2026

Efficacy and safety of cabozantinib (CABO) in advanced neuroendocrine tumors (NET) according to hormone functional status: Subgroup analysis of phase 3 CABINET trial (Alliance …

N Trikalinos, SM Geyer, T Zemla, JR Strosberg, EM Wolin, ...

Journal of Clinical Oncology 44 (16_suppl), 4178-4178

Eileen O'Reilly
2026

Endoscopic Ultrasound-Guided Biomarker Evaluation of Pancreatic Cancer After Exposure to Therapy

SE Lee, D Kim, V Rolston, E Vakiani, C Sigel, EM O'reilly, K Yu, ...

Endoscopy 58 (S 03), OP161

Eileen O'Reilly
2026

ESMO podcast on upper GI cancers: highlights in hepatocellular carcinoma and pancreatic cancer from ESMO 2025

J Dekervel, A Vogel, E O’Reilly

ESMO Gastrointestinal Oncology 11

Eileen O'Reilly
2026

Establishing the minimum future liver remnant volume for safe hepatectomy

JA Steinharter, J Chou, CH Ilagan, M Gönen, LV Saadat, K Soares, ...

Journal of the American College of Surgeons 242 (6), 1671

Eileen O'Reilly
2026

Evaluating the Prognostic Impact of IDH Mutations in Intrahepatic Cholangiocarcinoma

Harvey RN, Gelfer R, Drill E, Balachandran V, D'Angelica M, Drebin J, Kingham TP, Saadat L, et al.

JCO Precis Oncol

Eileen O'Reilly
2026

Evaluating the prognostic impact of IDH mutations in intrahepatic cholangiocarcinoma.

R Gelfer, R Harvey, EN Drill, VP Balachandran, MI D'Angelica, JA Drebin, ...

Journal of Clinical Oncology 44 (2_suppl), 598-598

Eileen O'Reilly
2026

Evaluation of progression-free survival as a surrogate endpoint for overall survival in localized pancreatic cancer: Trans-Atlantic Pancreatic Surgery Consortium Study

J Okui, MG Besselink, AC Wei, EM O’Reilly, BG Koerkamp, S Ceuppens, ...

Annals of Surgical Oncology, 1-9

Eileen O'Reilly
2026

Excellent 2-and 3-Year OS after Ablative MRgRT for Localized Pancreatic Cancer without Surgery

M Reyngold, V Kirichenko, E O'Reilly, M Mcmillan, AJ Wu, PB Romesser, ...

International Journal of Radiation Oncology* Biology* Physics 126 (1), S250-S251

Eileen O'Reilly
2026