JCI 2026 · 04/30/2026
Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer
Presented by Wungki
Review summary
Examines how oncogenic KRAS signaling through the ERK/JUNB axis suppresses GATA6, a regulator of epithelial differentiation, and how loss of GATA6 relates to the more aggressive, less-differentiated state of pancreatic cancer.